Skeletal Rearrangements as Strategies for the Total Syntheses of Indole Alkaloids

Xiaoni Xie; Liansuo Zu

doi:10.1055/s-0036-1591560

Synlett, Table of Contents

Synlett 2018; 29(08): 1008-1013
DOI: 10.1055/s-0036-1591560

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Skeletal Rearrangements as Strategies for the Total Syntheses of Indole Alkaloids

Authors

Xiaoni Xie

School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, P. R. of China Email: zuliansuo@biomed.tsinghua.edu.cn
Liansuo Zu *

School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, P. R. of China Email: zuliansuo@biomed.tsinghua.edu.cn

Abstract

All articles of this category

Dedicated to Professor Neil K. Garg for leading L. Zu into the field of total synthesis

Abstract

In this account, we summarize our recent efforts in the total syntheses of several indole alkaloids, including minfiensine, calophyline A, deformylcorymine, strictamine, and goniomitine. Our central theme is to utilize skeletal rearrangements as key strategies for generating complex structures.

1 Introduction

2 The Development of an Aza-Pinacol Rearrangement

3 Applications of Aza-Pinacol Rearrangements in Total Syntheses

4 Strategy Extension: The Total Synthesis of Goniomitine

5 Conclusion

Key words

akuammiline - indole alkaloids - natural products - total synthesis - rearrangement

Full Text

References

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